10/27/2022 0 Comments Spy kit universal mailerDifferential transcription of genes influenced by covR also was identified in mouse soft-tissue infection. CovR also plays a central role in gene regulatory networks by influencing expression of genes encoding transcriptional regulators, including other two-component systems. Using DNA microarrays and quantitative RT-PCR, we found that CovR influences transcription of 15% ( n = 271) of all chromosomal genes, including many that encode surface and secreted proteins mediating host–pathogen interactions. Inactivation of covRS results in enhanced virulence in mouse models of invasive disease. A two-component regulatory system, designated covRS ( cov, control of virulence csrRS), negatively controls expression of five proven or putative virulence factors (capsule, cysteine protease, streptokinase, streptolysin S, and streptodornase). Group A Streptococcus, the causative agent of mild infections and life-threatening invasive diseases, produces many virulence factors that promote survival in humans. Two-component gene regulatory systems composed of a membrane-bound sensor and cytoplasmic response regulator are important mechanisms used by bacteria to sense and respond to environmental stimuli.
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